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Processes including spray-drying, hot melt extrusion and KinetiSol? Dispersing, are useful processes for formulating poorly water soluble drugs in order to improve their properties, such as wetting, dissolution and bioavailability. Polymers are typically employed in these processes to formulate the drug as an amorphous solid dispersion. Spray-drying requires that the drug is soluble in a suitable organic solvent. Thermally labile drugs and drugs that have a high melting point(e.g., greater than 200 ℃) are often not suitable to be processed using hot melt extrusion. KinetiSol? Dispersing, a high energy fusion process not requiring an external heat source, offers a suitable alternative to these difficult to formulate drugs. Processing considerations differ in terms of such parameters as processing time and stability to heat and shear. This talk will compare and contrast formulation considerations involved in process selection to make amorphous solid dispersions, and will include examples of formulations and processes showing enhanced properties.