Relatively higher incidence of KRAS codon 61but lower BRAF exon 15 mutations in Chinese colorectal c

来源 :22nd Asia Pacific Cancer Conference(第22届亚太抗癌大会) | 被引量 : 0次 | 上传用户:huang_hh
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Objective: To epidermal growth factor receptor-targeted monoclonal antibody therapy.This study aimed to elucidate the KRAS and BRAF mutant statuses in 674 Chinese colorectal cancer patients and to investigate their association with clinicopathological parameters.Methods: Direct sequencing was used to detect KRAS mutation(codons 12 and 13 in exon 2; codon 61 in exon 3) and BRAF mutation (codons 461 to 468 in exon 11; codon 600 in exon 15).
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