Neonatal glucocorticoids (GCs) treatment, in particular dexamethasone (DEX), has been frequently and effectively used for the prevention of chronic lung disease (CLD) in prematurely born children.Recent studies pointed out that the neonatal DEX treatment alters hippocampal synaptic plasticity in juvenile.The current study is aimed to evaluate the long-term effect of neonatal DEX treatment on amygdale.Male adult Wister rats were subjected to subcutaneous injection (sc) of tapering doses of DEX (0.5 mg/kg, 0.3 mg/kg and 0.1 mg/kg)from postnatal day 1 to 3.