OBJECTIVE To study the effects of taurine magnesium coordination compound (TMC) against cesium chloride-induced arrhythmia in the rabbit heart to discern the mechanism of TMC antiarrhythmic action.MET
Angiotensin Ⅱ (Ang Ⅱ) activates Rho-kinase and initiates the contractile activity in vascular smooth muscle.In this study, we investigated the vasorelaxing effect of DL0805, a Rho-kinase inhibitor, on
Cerebral ischemia and reperfusion is one of the leading causes for death and severe disabilities in the world and often lead to irreversible brain damage over later lifespan.The aim of this study was
Ginsenoside Rg1 (Rg1), one of the main active components of Panax ginseng, has been demonstrated to inhibit proliferation of vascular smooth muscle cells (VSMCs) induced by tumor necrosis factor-α in
OBJECTIVE Acidosis-induced [Ca2+]i transients emerged in heart ischemia is an old story.Currently, three mechanisms are involved in the Ca2+ transients in cardiomyocytes: a.the activation of Na +/H +
OBJECTIVE The present study was desighed to determine the causative links and precise correlations among microglial activation, the ATP-gated P2X7 purinergic receptor cation channel, and neuronal dege
OBJECTIVE The present study was desighed to determine the causative links and precise correlations among nitrosative stress, the cellular autophagy-lysosome process, and neurovascular damage during ce
The present study tested the hypothesis that induction of autophagy by producing appropriate amount of ER stress and autophagy activation is associated with neuroprotection in a rat model of focal cer
OBJECTIVE Comparative evaluations of cellular toxicity, lipophilicity and in vitro transmembrane transport of eight cerebrovascular protection flavonoids including puerarin, rutin, hesperidin, quercet
目的 膀胱过度活动症(OAB)严重影响患者生活质量,目前发病机理尚不清楚,本文研究了多胺在OAB发病机制中的作用.方法 临床获取人OAB和对照组膀胱上皮组织并进行组织培养,在培养的膀胱上皮细胞(BUC)上,利用高压液相检测多胺(腐胺,亚精胺,精胺)的细胞内水平,特异性抑制多胺合成酶后对多胺水平的影响;细胞内显微测钙技术和酶联免疫吸附试验(ELISA)分别观察多胺对胆碱能受体激动诱导的BUC内钙动员