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  5. Large diameter microbubbles produced by a catheter-based microfluidic device for sonothrombolysis ap

Large diameter microbubbles produced by a catheter-based microfluidic device for sonothrombolysis ap

来源 :2015两岸超声技术与医学研讨会 | 被引量 : 0次 | 上传用户：xtepnui2020
【摘 要】
：
Background, Motivation and Objective Sonothrombolysis clinical trials have utilized microbubble (MB) formulations with MB diameters between 1–4 μm.The restriction on MB size is due to a risk of gas em
【作 者】
：
Adam Dixon Brian Shin Vamsi Meka Joseph Kilroy Alexander Klibanov John Hossack 
【机 构】
：
Biomedical Engineering, University of Virginia, Charlottesville, VA, USA
【出 处】
：
2015两岸超声技术与医学研讨会
【发表日期】
：
2015年5期
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Background, Motivation and Objective Sonothrombolysis clinical trials have utilized microbubble (MB) formulations with MB diameters between 1–4 μm.The restriction on MB size is due to a risk of gas emboli formation and caused MBs outside of this diameter range to be unexplored for thrombolysis.However, large MBs confer increased bioeffects when excited acoustically, as has been shown in sonoporation and blood brain barrier disruption studies.In this work, we demonstrate that MBs in the 10-30 μm diameter range increase sonothrombolysis rates by up to 4.5X when compared to small MBs of ~2 μm diameter.
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