Investigation of somatic tumor mutations and single-nucleotide polymorphisms(SNPs) in ATAD5

来源 :The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern | 被引量 : 0次 | 上传用户:zhsotanlb
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  The maintenance of genome integrity is important in all cells.To conserve genome integrity, cells developed multiple molecular pathways to repair damaged DNA.Proliferating Cell Nuclear Antigen (PCNA), which is a homotrimeric ring-structure complex plays an important role in coordinating the replication fork-associated process during the DNA damage response and replication.PCNA functions as a clamp for DNA replication proteins and a platform for multiple DNA repair enzymes.
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