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Ubiquitination-mediated regulation of apoptosis signaling has long been postulated.We had showed that HECTD3, a new HECT domain-containing E3 ubiquitin ligase, contributes cell to apoptosis resistance in both intrinsic and extrinsic apoptosis pathway.For clarifying the mechanism of HECTD3 function, it is necessary to indentify substrates of HECTD3.