【摘 要】
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Objective Bone mass is maintained through a balance between osteoblast and osteoclast activity.Osteoblasts regulate osteoclast formation through their expression of RANKL and OPG in response to a vari
【机 构】
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300052 天津医科大学总医院内分泌科;University of Rochester Medical Center, Rochester, NY, USA
【出 处】
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中华医学会第九次全国内分泌学学术会议
论文部分内容阅读
Objective Bone mass is maintained through a balance between osteoblast and osteoclast activity.Osteoblasts regulate osteoclast formation through their expression of RANKL and OPG in response to a variety of factors.Recent studies have shown that chondrocytes may also regulate osteoclast formation through their expression of RANKL and OPG.β-catenin is a central molecule in canonical Wnt signaling and plays a critical role in controlling mesenchymal stem cell differentiation,bone and cartilage development and OPG expression by osteoblasts.
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