几丁质酶抑制剂的合成方法与活性研究

来源 :中国化学会第十三届全国有机合成化学学术研讨会 | 被引量 : 0次 | 上传用户:jay12
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  拟三糖allosamidin 1 (Scheme 1)是有效的18家族几丁质酶抑制剂,其具有杀虫和抗真菌活性.但allosamidin类化合物的合成是相当困难的,它是一具有挑战性的课题.分别用固-液相和全固相两种方法合成allosamidin类化合物.固-液相方法实现allosamidin类化合物的部分固相合成;全固相方法大大简化分离纯化的过程.而且,发现易于合成的N,N-二乙酰基-β-几丁二糖allosamizoline对一些几丁质酶的抑制活性强于难合成的allosamidin 1.
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