【摘 要】
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Background and Aim of Study: This study investigated the therapeutic effect of topical diphenylyclopropenone(DPCP) immunotherapy in Chinese patients with alopecia areata (AA) and its predictors of res
【机 构】
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Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road
【出 处】
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第十届四川·重庆皮肤性病学术会议暨四川省医学会第十三次皮肤性病学术会议
论文部分内容阅读
Background and Aim of Study: This study investigated the therapeutic effect of topical diphenylyclopropenone(DPCP) immunotherapy in Chinese patients with alopecia areata (AA) and its predictors of response or resistance to treatment through convenient serum tests.Method:A total of 84 patients with AA were treated with DPCP.Serum cytokine levels were measured in 33 patients pre-and post-treatment and 18 healthy controls using ELISA.Results:The rate of response to DPCP with satisfactory hair regrowth was 56.1%, correlated negatively only with hair loss area.Pre-treatment serum IgE levels were significantly higher in adverse side-effects group than in treatment responders group.Compared with pre-treatment, it was noted that alopecic patients had remarkably higher serum levels of Th1 cytokinessuch asIFN-γ and IL-12 when compared to healthy controls.Post-treatment levels ofIFN-γ and IL-12were significantly decreased,and levels of IL-4 and IL-10 were increased only in the responder group.Elevated pre-treatment serum IL-4 was found in the non-responder group.Also, there was a decrease in IL-12 pre-treatmentserum levels and anincrease in IL-12 and decrease in IL-10 post-treatmentserum levelsin the non-responder group as compared to the responder group.Conclusions: Elevated pre-treatment serum IL-4 and decreased post-treatmentserum IL-10 levels can be used as prognostic markers of poor DPCP therapeutic effect, whereas elevated pre-treatment serum IL-12 can be used as a prognostic marker of great DPCP therapeutic effect.And elevated pre-treatment serum total IgE levels may be used to predict severe adverse side-effects.The therapeutic effect of DPCP topical immunotherapy in AA is mainly through correction of imbalanced Th1/Th2.
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