【摘 要】
:
Fragile X syndrome (FXS),caused by silencing of the fmr1 gene,is the most common form of inherited mental retardation.Epilepsy is reported to occur in 20 to
【机 构】
:
Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sci
【出 处】
:
中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
论文部分内容阅读
Fragile X syndrome (FXS),caused by silencing of the fmr1 gene,is the most common form of inherited mental retardation.Epilepsy is reported to occur in 20 to 25% of individuals with FXS.However,no overall increased excitability has been reported in fmrl knockout (KO) mice,except for increased sensitivity to auditory stimulation.We examined here the influence of seizure activity on the expression of fmr1 mRNA and protein (FMRP) in the forebrain,and the role of FMRP in the kindling model of limbic epileptogenesis.We found that kindling increased the levels of fmr1 mRNA and protein in an activity-dependent manner in the wild-type mice.The development of kindling was dramatically accelerated in the fmr1 KO mice.Furthermore,the fmr1 KO mice displayed prolonged electrographic seizures during kindling and more severe mossy fiber sprouting after fully kindled.Our data revealed that FMRP plays a critical role in activity-dependent regulation of neuronal excitability and limbic epileptogenesis.
其他文献
Objective In the present study,the effects of haloperidol,clozapine and olanzapine on acquisition,consolidation and retrieval processes of learning and memo
目的:构建持续膀胱冲洗(CBI)引流液颜色评估工具,探索其临床价值。方法:通过文献回顾、专家会议、实践研制等方法构建CBI引流液颜色评估工具(暂定版),并对其进行一致性检验及完善,形
背景:口腔治疗中牙弓形态常被认为是一个重要的因素,但其三维有限元模型暂未被建立.目的:建立模拟正畸治疗后方圆型、卵圆型、尖圆型牙弓形态的三维有限元模型.方法:选取1例
Transplantation of Schwann cells (SCs) and olfactory ensheathing cells (OECs) have emerged as very promising therapies for spinal cord repair.The important
Examination of ancient cultural layers will increase our knowledge about ancient urbanization and improve our understanding of urban soils and the processes
Objective To study the role of an autophagy/lysosomal pathway in 6-OHDA-induced death of dopaminergic cells in PD models.Methods In this study,we establishe
以最大限度经尿道膀胱肿瘤电切术(TURBT)为主的综合治疗方式是近年来膀胱癌治疗领域的新兴方向.对于不适合行根治性膀胱切除术或适合保留膀胱的肌层浸润性膀胱癌(M IBC)患者,
目的 采用腹腔注射槐定碱建立SD大鼠化学点燃癫痫模型,探讨谷氨酸(Glu)、γ-氨基丁酸(GABA)与癫痫发病机理的关系.方法 将40只成年SD大鼠随机分为对照组(10只)和模型组(3
Objective To develop assays for several single nucleotide changes using mutation-sensitive on/off switch and to apply these assays in DNA pool analysis.Meth
Objective Perinatal hypoxia-ischemia is an important cause of brain injury in newborns,with a high risk of future behavioral and neurological deficits.It is