AT2受体通过NO/cGMP/Sp1途径降低肾脏近曲小管AT1受体表达与功能

来源 :第二届中国高血压大会暨中国医师协会高血压专业委员会年会 | 被引量 : 0次 | 上传用户：qazzaq123

【摘要】

：

目的肾素-血管紧张素-醛固酮系统(RAS)是机体重要的体液调节系统,在血压调控、水盐代谢中发挥了重要作用.血管紧张素Ⅱ(Ang Ⅱ)是RAS系统的重要活性肽,在肾脏中主要通过AT1和AT2受体发挥作用.以往研究认为AngⅡ在肾脏的促进尿钠潴留等生物学效应主要通过AT1受体介导.

【作者】

：

杨剑陈彩宇任红梅韩愈何多芬周林曾春雨

【机构】

：

第三军医大学大坪医院心血管病专科医院心内科、重庆心血管病研究所

【出处】

：

第二届中国高血压大会暨中国医师协会高血压专业委员会年会

【发表日期】

：

2012年9期

【关键词】

：

AT2 受体 AT1 受体肾脏近曲小管上皮细胞钠排泄血压

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AT2受体通过NO/cGMP/Sp1途径降低肾脏近曲小管AT1受体表达与功能

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