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Background HLS5 belongs to the RBCC (Ring-finger,B-box,coiled-coil) family,a family of tumor suppressive genes including Pm,Tif1-α,Herf and Rfp,it has been reported to regulate erythroid differentiation,to be activated during the conversion of J2E erythroleukemic cells to monocytoid cells,and assumed to be a tumor supressor.However,the role of HLS5 in acute lymphoblastic leukemia has never been explored.