AIM To study the inhibitory effect on cell proliferation and explore anti-tumor mechanism of Saponins of asparagus.METHODS Saponins of asparagus with different concentration was treated with HepG2 and SGC-7901 at different time,MTT assay was used to detect inhibitory rate,fluorescence staining(PI) was used to observe apoptosis morphology,flow cytometry was used to detect apoptosis rate and cell cycle.