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Low toxicity and high transfection efficiency are among the most important preconditions for selecting a non-viral gene delivery carrier.Although calcium phosphate (CaP) presents high efficacy to condense nucleic acids,CaP particles grow quickly to form large agglomerates after preparation,causing reproducibility problems,which limit their applications[1].Up to now,various organic materials such as poly(D,L-lactide-co-glycolide acid) (PLGA)[2]has been ultilized to improve the stability of CaP nanoparticles.