Purpose: This study was aimed to investigate the genetic variation of PARP-1 involved in triggering the autoimmunity or inflammatory process causing GD.Method: The study was conducted among Chinese population;about 140 patients affected with GD/GO and age matched healthy individuals were enrolled in the study.Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) were used to examine the genotype and allele frequencies of PARP1 and NF-κB1 genes.Sandwich ELISA method was used to measure the cytokine levels.Result: The patients with GG genotype and carriers of G allele of PARP-1 G1672A polymorphism have shown the risk of having GD (p=0.0005), however patients having GA genotype may be protective against the disease.PARP-1 C410T polymorphism was found to be associated with GO by increasing the risk by 1.8 times (p=0.0222).Another risk factor for development of GO was the polymorphism of del/ins of NFkB1 gene (p =0.05) that increases the risk by 40%.Levels of cytokines were also elevated in patients with GD, however no relationship was found between levels of cytokines and the development of GO.Conclusion: The present findings suggest that the PARP1 (C410T and G1672A) polymorphisms are likely to be associated with the risk of developing GD/GO with the combination of NFkB1 polymorphism in Chinese population.