【摘 要】
:
In recent years many proteins produced in large quantities by recombinant DNA techniques have become important new drugs.However,protein drugs possess several shortcomings,including susceptibility to
【机 构】
:
Department of Pharmaceutical Sciences University of Padua Italy
【出 处】
:
2008中国深圳蛋白质和多肽科学大会
论文部分内容阅读
In recent years many proteins produced in large quantities by recombinant DNA techniques have become important new drugs.However,protein drugs possess several shortcomings,including susceptibility to degradation by proteases,short circulating half-life in vivo,low solubility,rapid kidney clearance and propensity to generate neutralizing antibodies.Among the techniques so far explored for the d.evelopment of safer and more useful protein drugs,undeniably the protein surface modification by covalent attachment of poly(ethylene glycol) (PEG) became an extremely valuable technique for producing protein drugs more water-soluble,non-aggregating,non-immunogenic and more stable to proteolytic digestion.
其他文献
Using magnetic nanoparticles as a drug targeting carrier or imaging agent has attracted attention recently.In this report,a protein drug urokinase (UK) targeted by magnetic nanoparticles will be prese
The recent SARS epidemic has boosted interest in the discovery of novel human and animal coronaviruses.By January 2008,more than 3000 coronavirus sequence records,including more than 250 complete geno
A novel pH and temperature sensitive penta-block (PAE-PCL-PEG-PCL-PAE (poly (β-amino ester))) was synthesized followed by preparing poly (ethylene glycol)(PEG)-Poly (ε-caprolactone (CL)) (PCL-PEG-PCL)
Matrix metalloproteinase-3 (MMP3) is well known as a secretory endopeptidase degrading extracellular matrices (ECM) and involved in many physiological and pathological processes.Recent reports indicat
Polymeric amphiphiles consisting of hydrophilic and hydrophobic segments can form micelles or micelle-like self-assemblies with a hydrophobic core and a hydrophilic shell due to non-covalent associati
An increasing number ofpeptides/proteins are being developed as therapeutic agents.However,peptides/proteins are generally much less stable than small molecule drugs.Their instability behavior greatly
The biological risks associated to the administration of viral vectors for gene therapy have restricted the further development of viral vectors and seriously challenged their incorporation to clinica