Current proteomic technologies are limited with respect to absolute quantification of protein levels and the amount of material required: large ensembles of cells are used.By working with population averages rather than their distributions, rare but important events are missed and systems such as heart progenitor cells that are only produced in small numbers cannot be readily analyzed.Further to this, protein levels are not homogenous throughout a cell and vary as a function time.In effect spatial and time-resolved-omics is not possible at present.