论文部分内容阅读
Purpose: Melatonin is a neuroendocrine hormone synthesized primarily by the pineal gland.Numerous studies have demonstrated that melatonin plays an important role in various in cardiovascular diseases.Large-conductance Ca2+-activated K+(BKCa)channels provide a negative feedback that regulates vascular tone in the brain circulation,studies have shown that melatonin could reduce the whole-cell BKCa current.