【摘 要】
：
Background.In order to create a large animal model to treat cardiovascular diseases using iPSCs,we generated iPSCs from pig myocardial fibroblasts,which presuma
【机 构】
：
CellularBiologySection,CardiothoracicSurgeryResearchProgramUSA
【出 处】
：
2015美中心血管病治疗前沿技术交流会
论文部分内容阅读
Background.In order to create a large animal model to treat cardiovascular diseases using iPSCs,we generated iPSCs from pig myocardial fibroblasts,which presumably have a higher tendency to differentiate into cardiac lineages due to epigenetic memory.This study was designed to test iPSC effects in vivo and compare to MSCs.Methods.P3 myocardial fibroblasts were used for reprograming using the lentiviral vector containing 4 human factors:OCT4,SOX2,KLF4,and cMYC.The iPSC Colonies at P12-17 were allogeneically transplanted into chronically ischemic myocardium of eight swine by direct intramyocardial injection.Cohorts of two animals were sacrificed at 2,4,6 and 8 wks after injection.
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