目的 利用探针药物法研究艾瑞昔布对大鼠体内CYP2C9酶的影响.方法 将大鼠随机分为实验组和对照组,每组18只,实验组每天灌胃艾瑞昔布20 mg·kg1-1,对照组每天灌胃等量蒸馏水,2次/天,连续7天.第8天,每只大鼠灌胃甲苯磺丁脲50 mg·kg-1,并于给药后24 h内眼内眦取血,高效液相色谱法测定血浆药物浓度,绘制药时曲线,DAS 2.1.1软件拟合药动学参数,使用SPSS 13.1软件对
Objectives The present study sought to determine the role of the NLRP3 inflammasome in MI/R injury and to investigate further the signalling pathways that lead to the activation of NLRP3 inflammasome
Objectives Picroside II, an iridoid glucoside found in the root of Picrorhiza scrophulariiflora Pennell (Scrophulariaceae), has been demonstrated to reduce apoptosis in neuronal cells and other cell t
Objectives To investigate the potential protective effect of Bosentan in diabetic cardiac complications.Methods Male C57BL/6 mice with 6-week old were divided into 3 groups (N =20) : Control group, DM
Objectives To investigate the relationship between plasminogen activator inhibitor-1(PAI-1) promotor region gene 4G/5G polymorphism and pulmonary thromboembolism (PTE) and detect whether it plays an i
Objectives To investigate the effects of the cell lines of saussurea medusa (CLSM) on regulating blood lipid in rats with hyperlipidemia.Methods A randomised controlled experimental Study.This study w
Objectives This study was designed to study the effect of PJS on TGF-β/Smads pathway after MI in rats.Methods Male Sprague-Dawley rats (9-10 weeks) were subjected to sham-MI or MI by ligating the left
Objectives Heart failure is associated with electromechanical alternans that often heralds the development of malignant arrhythmias and sudden death, but the exact mechanism is unclear.Our previous st
Objectives CaMKII activation is pro-arrhythmic in heart failure where myocardium is stretched.However, the arrhythmogenic role of CaMKII in stretched ventricle has not been well understood.
Objectives To explore the regulating lipid effects of Rosuvastatin on rats with dyslipidemia and its antiatherosclerotic effects.Methods Thirty-six mate SD rats were randomly divided into normal group