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目的：建立IgA肾病野生型及TLR4基因敲除小鼠模型，观察TLR4基因敲除对IgA肾病模型小鼠血液和尿液的生化指标、肾组织病理改变、肾脏IgA沉积及骨髓IgA淋巴细胞变化的干预效果，探讨TLR4在IgA肾病过程中的作用。
TLR4基因敲除对IgA肾病模型小鼠干预效果的观察
【摘 要】
：
目的：建立IgA肾病野生型及TLR4基因敲除小鼠模型，观察TLR4基因敲除对IgA肾病模型小鼠血液和尿液的生化指标、肾组织病理改变、肾脏IgA沉积及骨髓IgA淋巴细胞变化的干预效果，探讨TLR4在IgA肾病过程中的作用。
【机 构】
：
南昌大学第一附属医院 江西省中医药大学科技学院
【出 处】
：
中国免疫学会第十届全国免疫学学术大会
【发表日期】
：
2015年10期
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