Tolvaptan is an orally active vasopressin V2 receptor antagonist clinically used in the treatment of hyponatremia.Recently, U.S.FDA issued a black box warning for tolvaptan due to its high risk of liv
The db/db mice were a strain of mutant line from C57BL/6J mice, and it is always used as a human type 2 diabetes mellitus animal model.
Many plant-derived glycosides are used as medications.It is common that these glycosides show poor intestinal absorption but their metabolites generated by intestinal microflora demonstrate strong bio
Paeoniflorin (PF) and albiflorin (AF) are the main components of total peony glucosides (TPG), which has been widely used as the valuable monoterpene glycosides in Paeonia lactiflora Pall and have man
Objective Boswellia serrata was widely used in traditional medicine as an anti-inflammatory agent, 11-keto-β-boswellic acid (KBA) and 3-acetyl-11-keto-β-boswellic acid (AKBA) were the most potent BAs.
目的 确定人肝脏微粒体中蟾毒它灵的主要氧化代谢途径,并对参与其代谢的细胞色素P450酶亚型及其机制进行研究.方法 采用肝微粒体、重组酶体外代谢的孵育方法和液相色谱-串联质谱(LC-MS/MS)技术,分析孵育体系中蟾毒它灵及其代谢物,并使用特异性抑制剂、酶反应动力学和相关性分析实验进行验证实验,初步判断蟾毒它灵的主要代谢途径及其涉及的CYP同工酶,并用分子对接方法验证其代谢机理.结果 蟾毒它灵在人肝
Patients with diabetes have increased rates of cardiovascular events.Concomitant use ofantidiabetic agents and clopidogrel may increase the risk for drug interactions.
In this work, The blue luminescent carbon nitride dots (CNDs) with high quantum yield and strong photoluminescent are successfully synthesized via a facile and fast hydrothermal method using citric ac
The liposoluble drug roxithromycin owing to its high log P value was chosen to research whether the placenta barrier has protective effect on fetuses in late pregnancy.
溃疡性结肠炎(UC)状态下体内一些代谢酶的功能与表达会发生改变,且近期有报道使用质子泵抑制剂奥美拉唑(OME)治疗溃疡性结肠炎(UC),因此本研究考察OME在UC模型大鼠不同病期肝、肾、肠微粒体中奥美拉唑代谢酶活性的变化.给予大鼠自由饮用5％葡聚糖硫酸钠(DSS)7天诱导急性期UC(UCA)大鼠模型,7天DSS后改正常饮水7天诱导恢复期UC(UCR)大鼠模型.同时制备UCA、UCR以及正常对照(N