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Background EWS expression in Ewing sarcoma family tumors (ESFTs) is decreased due to thehaploinsufficiency elicited by chromosomal translocation.The abnormal expression levels of EWS and itsdownstream factors contribute to the manifestation of ESFTs.We previously reported thatPRAS40contributes to the manifestation of Ewing sarcoma family tumors (ESFTs).However,themechanismremains elusive.MethodsPRAS40 wassilenced using siRNAs.