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Acutobin isolated from Deinagkistrodon acutus venom has been used to prevent or treat stroke in patients.This defibrinogenating serine protease is a 39 kDa glycoprotein containing terminal disialyl-capped N-glycans at four Asn sites.After sialidase treatment,the enzyme showed similar catalytic activities toward chromogenic substrate,and cleaved the Aα chain of fibrinogen as efficiently as the native acutobin did.