2. 您的位置
3. 首页
4. 会议论文
5. Cytotoxic T lymphocyte antigen-4 down-regulates T helper 1 cells by increasing STAT3 expression in a

Cytotoxic T lymphocyte antigen-4 down-regulates T helper 1 cells by increasing STAT3 expression in a

来源 :中国免疫学会第十届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：scholar165

【摘 要】

：

Objective: The purpose of this study was to ascertain if cytotoxic T lymphocyte antigen-4 (CTLA-4) playing an important role in the occurrence and progress of acute graft-versus-host disease (GVHD).

【作 者】

：

Feng Zhu Jianlin Qiao Kai Zhao Wei Chen Qing-yun Wu Jiang Cao Wei Sang Yao Yao Ming-shan Niu Chun-ling Fu Ling-yu Zeng Zhen-yu Li Kai-lin Xu 

【机 构】

：

徐州医学院附属医院

【出 处】

：

中国免疫学会第十届全国免疫学学术大会

【发表日期】

：

2015年10期

【关键词】

：

cytotoxic T lymphocyte antigen-4 acute graft-versus-host disease STAT3 T helper 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Objective: The purpose of this study was to ascertain if cytotoxic T lymphocyte antigen-4 (CTLA-4) playing an important role in the occurrence and progress of acute graft-versus-host disease (GVHD).

其他文献

胞外ADP及其受体对巨噬细胞介导的抗菌免疫功能的调控作用和机制研究

背景：近年来的研究发现，核苷酸作为一种危险信号分子对激活巨噬细胞、调节炎症具有十分重要的作用。而对胞外核苷酸ADP在细菌感染过程中的功能及作用机制尚未有详细报道。方法：为此本课题首先建立了小鼠体内、外的细菌感染模型，并对细菌感染过程中胞外ADP的释放、受体表达以及ADP的抗菌作用进行了初步评价。

会议

ADP嘌呤受体巨噬细胞MCP-1细胞迁移

EPSs from a Candida parapsilosis strain in the treatment of Experimental Candida Vaginitis: Exerting

Microbial exopolysaccharides (EPSs), long-chain polysaccharides released by a variety of organisms, have gained considerable attention for their potential in multiple disease treatments.

会议

Candida parapsilosis exopolysaccharidesCandidaVaginitis

Clinical Characteristics and Genetic Profiles of Severe Combined Immunodeficiency: a Single Center E

Rationale: Severe combined immunodeficiency (SCID), a rare PID, is poorly characterized in China.We retrospectively reviewed patients with SCID refered to our hospital from 2004 to 2013, and summarize

会议

Severe combined immunodeficiencyHSCTgene mutationBCG

ZBTB24 promotes G0/G1-S cell cycle transition through inhibiting the expression of IRF-4 & Blimp-1 i

Objective: Mutations in gone ZBTB24 lead to autosomal-recessive immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome in some patients.

会议

ICF syndromeZBTB24cell cycleIRF-4Blimp-1Bcl-6

Deficiency of programmed cell death 4 attenuates atherosclerosis in hyperlipidemic mice through incr

Background: Programmed cell death 4 (PDCD4) is a newly defined transcriptional and translational inhibitor, and tumor suppressor.

会议

PDCD4atherosclerosisT cellsmacrophagesIL-10

Human gingival tissue-derived mesenchymal stem cells reduce the severity of murine acute-GVHD throug

Human gingival tissue-derived mesenchymal stem cells (GMSCs) are a convenient source of MSCs that have been shown to treat autoimmunc disease.

会议

GMSCsaGVHDinflammatory enviormentTregCD39

Atorvastatin-modified bone marrow-derived dendritic cells decrease Tfh and increase Breg in experime

Background: We previously demonstrated that atorvastatin induced immature dendritic cells (DCs) derived from spleen in vitro.

会议

Statindendritic cellsexperimental autoimmune myasthenia gravisfollicular help

IFN-r and TNF-a promote the abilities of human placenta-derived mesenchymal stem cells on expressing

Background aims.Mesenchymal stem cells (MSCs) and regulatory T cells (Treg) have been successfully used in treating autoimmune diseases accompanied by abundant inflammatory cytokines such as IFN-γ and

会议

mesenchymal stem cellshuman placentaTreg subsetsPDL2IFN-γTNF-α

Peptide inhibitors blocking PD-1/PD-L1 interaction for cancer immunotherapy

Aim: Blockade of the protein-protein interaction between the transmembrane programmed cell death 1 protein (PD-1) and its ligand PD-L1 emerges as a promising immunotherapy for treating cancer.

会议

Cancer immunotherapyTherapeutic peptideMirror-image phage displayProtein chem

小鼠原位气管移植模型中Th17细胞介导移植气道上皮损伤

目的：建立小鼠原位气管移植模型,研究Th17细胞对移植物的影响。方法：供受体按体质量配对后随机分为6组,同系移植组：C57BL/6→C57BL/6 (n=10)；同种移植组：BALB/c→C57BL/6 (n=10)；IL-17AAb组：BALB/c→C57BL/6,注射anti-IL-17A抗体(n=10)；IL-6 Ab组：BALB/c→C57BL/6,注射anti-IL-6抗体(n=10)；

会议

Th17细胞IL-17A气管移植气道上皮损伤闭塞性细支气管炎