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<正>Objective:The purpose of this pilot study was to investigate instant effects of Kinesio Tape(KT) on relieving major complaints of patients with acute ankle sprain(AAS). Method:40 AAS patients 1:1 matched in body mass index(BMI) and degree of injury were randomly divided into study group(applied KT and routine local modalities) and control group(only local modalities).20 cases were included in each group.Swelling girth,Visual Analogue Scale(VAS) and Self Assessed Function for Lower Quarter(SAF) were managed to evaluate the degree of swelling,pain and ankle function as a whole. Result:The baseline and related scale of AAS before treatment were not significantly different(P>0.05).Girth measured in study group were significantly better than that of control group at 1st and 3rd day(P<0.01,t = 4.449,t = 4.638).The tendency of VAS showed the same inclination as girth’s(P<0.01,t=4.783,t= 4.129).There were no significant differences in between two group at 5th day after therapy as far as VAS and girth were concerned,but the results of study group were still slightly larger than that of control group.The SAF showed significantly difference between 2 groups through the treating process(FSAF=11.733,P<0.05).No evidence of obviously allergic event was recorded. Conclusion:KT can be an effective method of integral therapy on AAS,and it invites further studies and clinical applications on this area.