【摘 要】
：
Cancer results from an accumulation of genetic and epigenetic aberrations.Genetic aberrations include chromosome number changes and translocations, gene amp
【机 构】
：
Karmanos Cancer Institute Wayne State University Medical School Detroit, MI USA
【出 处】
：
BIT‘s2nd Annual World Cancer Congess-2009 (2009第二届癌症大会)
论文部分内容阅读
Cancer results from an accumulation of genetic and epigenetic aberrations.Genetic aberrations include chromosome number changes and translocations, gene amplifications, mutations and deletions.Epigenetic abnormalities involve both altered patterns of histone modifications as well as losses and gains of specific DNA methylation.Genetic and epigenetic alterations in cancer cells interact directly and indirectly.In particular, epigenetic alterations can result from genetic alterations that dictate abnormal chromatin regulation.Specifically, a genetic alteration in the gene encoding an epigenetic enzyme can lead to changes within the histone code, which is involved in both tumorigenesis and cancer stem cell-generated hierarchies in multiple tumor types.
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