• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. Hes1 triggers epithelial-mesenchymal transition (EMT)-like cellular marker alterations and promotes

Hes1 triggers epithelial-mesenchymal transition (EMT)-like cellular marker alterations and promotes

来源 :2016华南实验动物科学国际研讨会、第三届实验小型猪国际论坛暨广东·九州实验动物学术交流会 | 被引量 : 0次 | 上传用户：gc_xyz
【摘 要】
：
Overexpression of the transcriptional factor Hes1 (hairy and enhancer of split-1) has been observed in numerous cancers,but the precise roles of Hes1 in epithelial-mesenchymal transition (EMT),cancer
【作 者】
：
Sheng-Chun Wang Xiao-Lin Lin Hui-Yan Wang Yu-Juan Qin Lin Chen Jing Li Jun-Shuang Jia Hong-Fen Shen Sheng Yang Rao-Ying Xie Fang Wei Fei Gao Xiao-Xiang Rong Jie Yang Wen-Tao Zhao Ting-Ting Zhang Jun-W 
【机 构】
：
Cancer Research Institute, Southern Medical University, Guangzhou 510515, China;Department of Pathol
【出 处】
：
2016华南实验动物科学国际研讨会、第三届实验小型猪国际论坛暨广东·九州实验动物学术交流会
【发表日期】
：
2016年10期
【关键词】
：
Hes1 nasopharyngeal carcinoma (NPC) epithelial-mesenchymal transition (EMT) canc 
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
　　Overexpression of the transcriptional factor Hes1 (hairy and enhancer of split-1) has been observed in numerous cancers,but the precise roles of Hes1 in epithelial-mesenchymal transition (EMT),cancer invasion and metastasis remain unknown.Our current study firstly revealed that Hes 1 upregulation in a cohort of human nasopharyngeal carcinoma (NPC) biopsies is significantly associated with the EMT,invasive and metastatic phenotypes of cancer.In the present study,we found that Hes1 overexpression triggered EMT-like cellular marker alterations of NPC cells,whereas knockdown of Hesl through shRNA reversed the EMT-like phenotypes,as strongly supported by Hes1-mediated EMT in NPC clinical specimens described above.
其他文献
Pre-pregnancy obesity reduces litter size in primiparous experimental minipigs
Obesity is a public health problem in both developed and developing countries.The negative effects of obesity on reproductive physiology have been highlighted in recent years.The aim of this study is
会议
minipiglitter sizeobesitysex hormoneleptininsulin
Expression of Bama minipig and human CYP3A enzymes,comparison of the catalytic characteristics with
Minipigs represent a good animal model because of the physiological and anatomical similarities they share with humans.Three cytochrome P450 (CYP) 3A isozymes,CYP3A22,3A29,and 3A46,have recently been
会议
A correlation study of boar taint-related genes,boar taint substances and sex hormones in Bama minia
The Bama miniature pig (Sus scrofa domestica),endemic in China,which is characterized by its small size and specific meat flavor.The evaluation of pork quality is closely related to boar taint.However
会议
AndrostenoneBama miniature pigBoar taintGene expressionSkatole
Effects of Angiotensin Ⅱ Type 2 Receptor Overexpression on the Growth of Hepatocellular Carcinoma Ce
Increasing evidence suggests that the renin-angiotensin system (RAS) plays an important role in tumorigenesis.The interaction between Angiotensin Ⅱ (AngⅡ) and angiotensin type 1 receptor (AT1R) may ha
会议
AAV-Mediated Angiotensin 1-70verexpression Inhibits Tumor Growth of Lung Cancer In Vitro and In Vivo
Angiotensin-(1-7)[Ang-(1-7)]is an endogenous,heptapeptide hormone with anti-proliferative and anti-angiogenic properties.Previous studies had shown that Ang-(1-7) can inhibit lung cancer cell growth b
会议
Single Point Mutation in Adeno-Associated Viral Vectors-DJ Capsid Leads to Improvement for Gene Deli
Background: Rational design of AAV capsids is a simple method for enhancing AAV transduction efficiency.AAV-DJ is a highly recombinogenic hybrid vector created from DNA shuffling of eight AAV serotype
会议
Point mutationAdeno-associated virus-DJIn vivoGene deliveryImprovement
Single tyrosine mutation at the 703 position of adeno-associated virus (AAV) serotype-8 capsid leads
Background: Single point mutation at specific tyrosine residues of AAV capsids has been reported as a simple and effective method for enhancing the efficiency of AAV-mediated gene transduction both in
会议
adeno-associated vector serotype-8capsid modificationtyrosine mutantdual-luci
Establishment of Loop-Mediated Isothermal Amplification Technique for Rapid Detection of Bluetongue
Bluetongue disese is one of the major domestic and wild ruminant viral diseases and has caused significant economic loss to cattle and sheep producers.In this study,a Loop-mediated isothermal amplific
会议
Bluetongue virusLAMPrapid detectionNS1 gene
Generation of Rm21LG transgenic mice: a powerful tool to generate conditional overexpression of miR-
miR-21 is highly expressed in a variety of cancers,suggesting that it might play a role in the process of oncogenesis,as supported by it directly causing pre-B cell lymphomas in transgenic mice.Rm21LG
会议
Cancer preventionConditional gene expressionCre/lox P systemmiR-21Oncogenesi
Cytokine-induced killer cells efficiently kill stem-like cancer cells of nasopharyngeal carcinoma vi
Cancer stem cells (CSCs) are considered to be the root cause for cancer treatment failure.Thus,there remains an urgent need for more potent and safer therapies against CSCs for curing cancer.In this s
会议
nasopharyngeal carcinomacytokine-induced killer cellscancer stem cellspromote