【摘 要】
：
FSH induced an immediate, dose-dependent intracellular Ca2+ elevation in rat SCs.The phosphatidylinositol-phospholipase C (PLC)-specific inhibitor (U73122),
【机 构】
：
GraduateInstituteofMedicalSciencesTaipeiMedicalUniversityTaiwan
论文部分内容阅读
FSH induced an immediate, dose-dependent intracellular Ca2+ elevation in rat SCs.The phosphatidylinositol-phospholipase C (PLC)-specific inhibitor (U73122), not Gs-specific inhibitor (NF449), inhibited the FSH-induced Ca2+-influx.The translocation of PLC-δ 1 to cell membrane and the formation of Gαh/PLC-δ 1 complexes occurred within 5 and 10 sec, respectively, of FSH exposure.The intracellular inositol 1,4, 5-triphosphate (IP3) production was also detected 30 sec after FSH treatment.A synthetic peptide of PLC-δ1 (TIPWNSLKQGYRHVHLL) predominantly inhibited the FSH-induced PL-δ 1 translocation, formation of Gαh/PL-δ 1 complex, IP3 production, and Ca2+ influx.
其他文献
We sought to determine if a common polymorphism can increase vulnerability to a modifiable risk factor for cardiovascular disease (CVD), and thereby influen
One of the purposes of developing health informatics is to enable the early detection, early diagnosis, and early treatment of diseases.Identified as one of
Channels selective for potassium ions come in many varieties, and have been adapted to many purposes.Most familiar are the signaling functions, such as repo
Last 5~6 years have been a period of revival of PET scanner and PET became an indispensible imaging tool for diagnosis of tumors and other metabolic abnorma
Appropriate regulation of the response to stress is critical for the maintenance of homeostasis.In mammals, the response is mediated by the hypothalamic-pit
Age-associated cognitive decline, memory in particular, is a typical consequence of aging and an increasing biomedical concern, as over 38 million individua
A sustained alteration of intracellular calcium homeostasis in neurons is a common feature in neurodegeneration, and plasma membrane calcium transport syste
Excess exposure to glucocorticoids during fetal life could program both short-term or long-term biological changes at cellular, tissue, organ, or body syste
In developing novel drugs for the treatment of metabolic disorders, there has been an increasing recognition of the importance of multi-faceted action.Accor