Objective:To observe the efficacy and tolerability of gemcitabine plus Yadanziyouru injection in elderly patients with advanced (stage IV) non-small cell lung cancer (NSCLC).Methods:25 patients with advanced NSCLC aged over 70 years with a performance status of 1-2 were received the treatment of low dose of gemcitabine combined with Yadanziyouru injection.Gemcitabine 800 mg/m2 was administered as a 30-min infusion once a week for 2 weeks foliowed by a week of rest,cycles were repeated every 3 weeks.Yadanziyouru injection 30 ml was administered as 90-min infusion once a day for 2 weeks followed by a week of rest.