【摘 要】
：
Widely recognized for their ability to produce a prolonged blood circulation time and facilitate tumor accumulation via the enhanced permeability and retention (EPR) effect,PEGylated liposomes hold gr
【机 构】
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National Key Laboratory of Biochemical Engineering,Institute of Process Engineering,Chinese Academy
【出 处】
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The Third Symposium on Innovative Polymers for Controlled De
论文部分内容阅读
Widely recognized for their ability to produce a prolonged blood circulation time and facilitate tumor accumulation via the enhanced permeability and retention (EPR) effect,PEGylated liposomes hold great promising applications for cancer therapy.Unfortunately,PEGylation significantly reduces the cellular uptake and endosomal/lysosomal escape of the liposomes,which interferes with the anticancer efficacy of liposome-based drug delivery system.Most importantly,it has been proved that repeated injections of PEGylated liposomes with cell cycle specific drugs such as topotecan (TPT) in the same animal at certain time intervals will induce "accelerated blood clearance" (ABC) phenomenon [1].In our previous study,it has been proven that PCBylation has superior ability in extending the blood retention without interfering with the endosomal/lysosomal escape of the liposomes due to the protonation of PCB in acidic condition,which is quite different from that of PEGylation [2].However,whether liposomes modified with PCB will stimulate ABC phenomenon in vivo has not been verified.
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