Carcinogenesis is a complex multistep process involving not only genetic and epigenetic changes within the rumor cells but also the reorganization of the connective tissue compartment leading to a specialized tumor microenvironment (TME).Investigating the complex functional interrelation between the cellular and non-cellular compartments of the rumor microenvironment has already led to the identification of new therapeutic targets.A review on important aspects in the interrelationship between tumor cells and the microenvironment leading to tumor progression, with focus on angiogenesis, and a summary on derived targeted therapies, including data of own clinical trials will be given.