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The renin-angiotensin system (RAS) plays important roles in tumorigenesis and is involved with several hallmarks of cancer.Evidence shows that angiotensin Ⅱ (AngⅡ) type 1 receptor (AT1R) blockers may be associated with improved outcome in prostate cancer patients.Furthermore,our previous studies indicate that increased expression of Ang Ⅱ type 2 receptor (AT2R) alone induced apoptosis in human prostate cancer lines,an effect that did not require Ang Ⅱ.