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Antibiotics are considered to be the main member of emerging pollutant,pharmaceuticals and personal care products.The fluoroquinolone and tetracycline antibiotics are named as β-diketones antibiotics(DKAs)because their molecular structures contain β-diketone function groups.DKAs can lead to environmental biological impedance,which have severe liver,kidney toxicity and neurotoxicity.Although some DKAs have weak hormone or mutagenic activity,they act on hormone-sensitive pathways and have synergistic effects with other factors,which lead to their great ecological risk.This study evaluated the effects of β-diketone antibiotics(DKAs)on the development of embryo-larval zebrafish(Danio rerio).