Objective In new definitions for sepsis and septic shock(Sepsis-3),Sepsis is now defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.Septic shock is a subset of sepsis with circulatory and cellular/metabolic dysfunction associated with a higher risk of mortality The object of this study is to explore the best kind of regimen of vasopressors treatment in septic shock.Methods Two investigators independently reviewed the identified abstracts and selected articles for full reviewing,and the discrepancies were resolved by the third reviewer.The reference lists of eligible studies and relevant papers were also manually searched and reviewed.The search terms were “septic shock”,and “vasopressor”,et al.The search date was until 2019/4/22.Inclusions criterion:(1)researched study about using vasopressors for treating septic shock,(2)outcome: 28-day mortality,(3)only be published by English.Exclusions criterion:(1)review,retrospective research,case report,(2)insufficient data in the articles.Finally we found 2517 articles,excluding 1374 duplications,then we included 46 articles through reading the title and abstract,and 31 studies were included.Results After searching and screening the articles,finally we included articles about 31 RCTs with patients,and 11 arms(dopamine,dopexamine,epinephrine,norepine phrine,norepinephrine+dobutamine,norepinephrine+dopexamine,norepinephrine+epinephrine,norepinephrine+vasopressin,Phenylephrine,terlipressin,vasopressin)with total 5928 patients with septic shock.Compared with dopamine,the regimens(epinephrine,norepinephrine,norepinephrine+dobutamine,and vasopressin)have significant lower 28-day mortality.Ranking the regimens in the order of estimated probabilities of each treatment by using the network meta-analysis,the result showed that norepinephrine+dopexamine was the best one(57.3%),followed by norepinephrine+epinephrine(14.8%),norepinephrine+dobutamine(10.9%),dopexamine(11.2%),terlipressin(9.8%),norepinephrine+vasopressin(2.4%),Phenylephrine(1.2%),epinephrine(1.0%),vasopressin(0.5%),norepinephrine(0.0%),and dopamine(0.0%).Combining therapy accounted on the best three therapeutic regimens.Conclusions Combination regimens of vasopressors accounted for the best three therapeutic regimens.For patient with septic shock,combining regimens probably get benefit.