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Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a recently discoverednegative regulator of multiple growth factor receptors,at least negating members of epidermalgrowth factor (EGF) receptor (EGFR) family (EGFR,ErbB2,ErbB3,ErbB4),hepatocyte growth factor (HGF) receptor (Met),and glial cell line-derived neurotrophic factor(GDNF) receptor (Ret).The extracellular domain (LRIG1 ectodomain) of LRIG1 has beenfound to interact with the extracellular domain of EGFR and physically interact with the Retreceptor.Our previous research showed that the LRIG1 ectodomains are shed and negativelyregulate cell proliferation and EGF signaling.