【摘 要】
：
Lead(Pb)is an environmental neurotoxic metal.Pb exposure may cause neurobehavioral changes,such as learning and memory impairment,and adolescence violence among children.Previous animal models have la
【机 构】
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Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard As
【出 处】
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第九届海内外华人神经科学家研讨会(The 9th Symposium for Chinese Neuroscientis
论文部分内容阅读
Lead(Pb)is an environmental neurotoxic metal.Pb exposure may cause neurobehavioral changes,such as learning and memory impairment,and adolescence violence among children.Previous animal models have largely focused on the effects of lead exposure during early development(from gestation to lactation period)on neurobehavior.In this study,we exposed Sprague-Dawley rats during the juvenile stage(from juvenile period to adult period).We investigated the synaptic function and structural changes and the relationship of these changes to neurobehavioral deficits in adult rats.Our results showed that juvenile Pb exposure caused fearconditioned memory impairment and anxiety-like behavior,but locomotion and pain behavior were indistinguishable from the controls.Electrophysiological studies showed that the long-term potentiation induction was affected in Pb-exposed rats.This probably due to excitatory synaptic transmission impairment in Pb exposed rats.Because we found NMDA and AMPA receptor mediated current was inhibited whereas the GABA synaptic transmission was normal in Pb-exposed rats.And NR2A and phosphorylated GluR1 expression was decreased.Moreover,morphological studies showed density of dendritic spines declined by about 20%in the Pb-treated group.The spine showed an immature form in Pb-exposed rats,as indicated by spine size measurements.However,the length and arborization of dendrites was unchanged.Our results suggested that juvenile Pb exposure in rats is associated with alterations in the glutamate receptor,which caused synaptic functional and morphological changes in hippocampal CA1 pyramidal neurons,thereby leading to behavioral changes.
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