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G protein-coupled receptors(GPCRs)are major players in cell communication.Growing evidence has indicated that some GPCRs can function as not only homodimers but also heterodimers,but the mechanism of how ligand binding leads to the activation of effector domain within these GPCR dimers remains elusive.The well-characterized dimers,metabotropic glutamate receptors(mGluRs)and theγ-aminohutyric acid receptor(GABAB receptor)play key role in the modulation of many synapses.