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Objective To evaluate synthetically the effect of CYP3A5*3 genetic polymorphism on the risk of childhood acute lymphoblastic leukemia (ALL).Methods Case-control studies investigating the relationship between CYP3A5*3 genetic polymorphism and childhood ALL risk were included by searching PubMed,Elsevier,EMBASE,China Biological Medicine Database,China National Knowledge Infrastructure platform and Wanfang Database.