Purpose Retrospective analysis of 1,2-dichloroethane toxic encephalopathy with paint using magnetic resonance imaging (MRI) imaging.Materials and Method 12 patients with 1,2-DCE toxic encephalopathy disease (8 males and 4 females,aged from 23 to 60 years old) were treated in our hospital from February 2006 to June 2013.They all had work history of 1,2-DCE exposure (types of footwear adhesive workers).Minimum hours of work over two months after the longest two years of symptoms,February 2009 to 2013 in June with 15 cases of toxic encephalopathy in patients with paint in my hospital.Including 12 males and 3 females,aged 19-60 years old.Using MRI scans of the head on GE MR machine,spin echo (SE) sequences imaging,T1-weighted imaging (T1WI): repetition time (TR) 300ms,echo time (TE) 15ms,T2-weighted imaging (T2WI): TR 4000ms,TE 108ms,fluid-attenuated inversion recovery sequence (FLAIR): TR 8000ms,TE 96ms,inversion time 2000ms; each of seven cases of patients underwent enhanced MR scan contrast agent gadolinium-DTPA using 15ml,thickness 8mm,layer from 2mm.Results 15 cases with toxic encephalopathy paint and 12 cases with 1,2- dichloroethane toxic encephalopathy white matter showed different forms of abnormal signal,T1WI had low signal,T2WI had high signal,FLAIR also demonstrated slight hyperintense.Conclusion The signal of white matter of patients with 1,2-dichloroethane toxic encephalopathy with paint was different.Clinical relevance/Application MRI is valueable to differentiate and diagnose the toxic encephalopathy with 1,2-dichloroethane toxic encephalopathy with paint.