【摘 要】
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OBJECTIVE Cisplatin-induced nephrotoxicity has been characterized previously in animals and humans.Two studies were conducted in cynomolgus macaques to assess the nephrotoxicity of cisplatin and to co
【机 构】
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Centre for Drug Safety Evaduation and Research, Shanghai Institute of Materia Medica Shanghai 201203
【出 处】
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2013年(第三届)中国药物毒理学年会暨药物非临床安全性评价研究论坛
论文部分内容阅读
OBJECTIVE Cisplatin-induced nephrotoxicity has been characterized previously in animals and humans.Two studies were conducted in cynomolgus macaques to assess the nephrotoxicity of cisplatin and to correlate the pathogenesis of lesions in the kidneys with expression of a panel of potential urinary biomarkers of kidney toxicity.METHODS In study #1,6 monkeys (1/sex/group) were given a single i.v.infusion of cisplatin (1.25, 2.5 and 5 mg· kg-1) and were terminated for necropsy on day 7 post-dose.In Study #2, 36 monkeys (3/sex/group) were given a single iv infusion of vehicle or cisplatin (2.5 mg·kg-1) and then they were terminated for necropsy on days 2, 5, 10 or 21, respectively,post-dose.
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