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  5. Innate and adaptive immune responses correlate with Peginterferon alfa treatment efficacy in chronic

Innate and adaptive immune responses correlate with Peginterferon alfa treatment efficacy in chronic

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：jiangfan520
【摘 要】
：
Objective: The aim of this study was to characterize the immunological features responsible for improved treatment responses in 77 patients with chronic hepatitis B (CHB) treated with peginterferon (P
【作 者】
：
Weiming Yan Di Wu Xiaojing Wang Tao Chen Qintao Lai Qi Zheng Jiaji Jiang Jinlin Hou Meifang Han Qin Ning 
【机 构】
：
Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong Un
【出 处】
：
中国免疫学会第九届全国免疫学学术大会
【发表日期】
：
2014年8期
【关键词】
：
Innate Immune Response Adaptive Immune Response Peginterferon alfa Entecavir Chr 
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Objective: The aim of this study was to characterize the immunological features responsible for improved treatment responses in 77 patients with chronic hepatitis B (CHB) treated with peginterferon (Peg IFN) alfa-2a after switching them from entecavir (ETV) therapy.Design: Peripheral natural killer (NK) cells, Toll-like receptors (TLRs), T cells, regulatory T cells (Tregs) and programmed death 1 (PD-1) were evaluated dynamically by flow cytometry.Response was defined as hepatitis B e antigen (HBeAg) seroconversion, hepatitis B surface antigen (HBsAg) loss, and HBsAg seroconversion (either as singular events or in combination at week 48)
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