We compared imaging and pathological changes between argon-helium cryosurgical (AH) and microwave (MW)ablation in a porcine liver model.Immediately after ablation, computed tomography (CT) imaging showed that the area affected by MW ablation was considerably greater than that affected by AH ablation;moreover, the surface area of necrotic tissue was considerably greater in the AH group, whereas the depth of the necrotic area was similar.Seven days after ablation, the affected area had not changed much in the AH group, but it had significantly increased in the MW group;similarly, the surface and depth of the necrotic areas had not changed much in the AH group, but they had increased significantly in the MW group.The pathological findings showed similar definitive areas for both groups at both time points.The findings indicated that long time after both therapies, complete tissue necrosis can be achieved, but the extent and depth of necrosis differ: necrosis foci after AH ablation could be predicted by ice ball under CT image, and necrosis foci after MW ablation will increase obviously.MW ablation might therefore be suitable for tumors with a larger volume and simple anatomical structures, and AH ablation might be suitable for tumors with complex anatomical structures or those located near important organs.These two methods could therefore be used in combination in clinical settings, but details of the procedure need to be studied.