【摘 要】
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Background and object The most effective way to contain cerebral ischemic injury is reperfusion, however, reperfusion itself may result in tissue injury, for which inflammatory damage is one of main c
【机 构】
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Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR
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Background and object The most effective way to contain cerebral ischemic injury is reperfusion, however, reperfusion itself may result in tissue injury, for which inflammatory damage is one of main causative factors.NALP3 inflammasome is a multiprotein complex.It consists of NALP3, ASC and caspase-1, whose function is to switch on the inflammatory process.Chrysophanol is an extract from plants of Rheum genus and it possesses many pharmacological effects including its anti-inflammation activity.In this study, the effects of chrysophanol in cerebral ischemia/reperfusion and the potential mechanisms were investigated.
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