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Background: Thousands of paraquat (PQ)-poisoned patients continue to die, particularly in developing countries.plasma perfusion has recently been incorporated as a method of clinical detoxification.The purpose of this study was to estimate the paraquat clearance of plasma perfusion, and observe the effect of plasma perfusion on paraquat concentration in the blood of patients with acute paraquat poisoning.Methods :21 PQ-poisoned patients admitted to our poisoning center within 24 hours after the ingestion were prospectively enrolled.Continuous plasma perfusion (flow rate 180 ml/min) was performed, with plasma/blood separation at 40 nl/min and routine cartridges change every 3 hours.Urinary PQ (UPQ), urine flow rate (UFR), and plasma PQ (PPQ) concentration level at inlet/outlet of the cartridge were obtained right before, and 1.5 hours after the start of each perfusion session for calculation of renal and plasma PQ excretion.Results:In all 8 rounds (108 sessions) of plasma perfusion on the 21 patients, PQ clearance rate (ml/min) by plasma perfusion was found always higher than the renal value: [1st (21 cases) 11.14 6.13 vs.6.53 1.46; 2nd (21 cases) 18.36 11.32 vs.6.23 1.51; 3rd (21 cases) 16.13 10.05 vs.4.01 0.93; 4th (17 cases) 12.86 (6.72, 17.47) vs.2.42 (0.65,4.20);5th (11 cases) 14.12 (10.48, 35.20) vs.1.77 (0.63, 2.91);6th (7 cases) 16.47 (t1.82; 20.69) vs.1.70 (0.23, 3.18); 7th (5 cases) 13.33 (9.71, 18.75) vs.1.10 (0.14, 2.99); 8th (5 cases) 11.27 (9.21, 16.02) vs.1.10 (0.09, 2.79), P<0.05 orP<0.01].The survivors (10 cases) showed a higher PPQ reduction rate (mg L-1h-1) than the non-survivors (11 cases, 0.57 0.03 vs.0.47 0.06,P<0.05).Conclusion: Our data show that plasma perfusion therapies help in the clearance of PQ and may prove a promising therapeutic tool in patients with acute PQ intoxication.