【摘 要】
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Fatty liver fibrosis, a severe type of Nonalcoholic fatty liver disease (NAFLD), can be reversed by effective medical intervention.Endoplasmic reticulum stress promotes liver fat accumulation and indu
【机 构】
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Medical College of China Three Gorges University,Yichang 443002,China
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Fatty liver fibrosis, a severe type of Nonalcoholic fatty liver disease (NAFLD), can be reversed by effective medical intervention.Endoplasmic reticulum stress promotes liver fat accumulation and induction of inflammatory cytokines, which plays an important role in the process of liver fibrosis.Our previous study have shown that, SPJ(saponins of Panax Japonicus) has significant antioxidant and antiinflammatory activity.Therefore, the protective effects and mechanisms of SPJ against fatty liver fibrosis in mice were investigated.In this study, fatty liver fibrosis was induced by highfat diet combined with intraperitoneal injection of heterologous protein.The results showed that SPJ significantly improved liver function and decreased the serum lipid level.SPJ remarkly decreased the liver steatosis, collagen fibers and inflammatory cell infiltration.Furthermore, treatment with SPJ significantly downregulated the mRNA level of Collagen Type Iα (COLL Ⅰα), αSMA, TIMP, CHOP and GRP78.In addition, SPJ significantly decreased the protein level of pJNK, COLL Ⅰα and GRP78.Taken together, SPJ protect against fatty liver fibrosis through inhibition of endoplasmic reticulum stress response and CHOP and JNKmediated apoptosis and inflammation pathway.These results indicate that SPJ might be a potential drug for prevention of liver fibrosis.
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