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5. Endoplasmic reticulum stress aggravation as the mechanism underlying Guttiferone K-induced apoptosis

Endoplasmic reticulum stress aggravation as the mechanism underlying Guttiferone K-induced apoptosis

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：renbaoshouxian

【摘 要】

：

Aim: Guttiferone K (GutK) is a novel cytotoxic compound able to selectively induce apoptosis in colorectal cancer cells.The study proposes endoplasmic reticulum (ER) stress aggravation as the underlyi

【作 者】

：

Kai-kei MIU Kenneth Kin-wah TO Hong-xi XU Ge LIN 

【机 构】

：

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT,

【出 处】

：

The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

：

2013年4期

【关键词】

：

Guttiferone K endoplasmic reticulum aggravation cancer selectivity apoptosis 

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Aim: Guttiferone K (GutK) is a novel cytotoxic compound able to selectively induce apoptosis in colorectal cancer cells.The study proposes endoplasmic reticulum (ER) stress aggravation as the underlying mechanism of action in GutK-induced apoptosis and suggests such mechanism as the rationale of its cancer selectivity.

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