【摘 要】
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Melanoma, a cancer that arises from melanocytes is one of the most unresponsive cancers to known therapies.Extensive attention has focused on the development of new and improved methods for tackling t
【机 构】
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Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, 866＃ Yuhangtang
【出 处】
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2013年中国药物制剂大会——中国药学会药剂专业委员会2013年学术年会暨国际控释协会中国分会2013年学术年会
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Melanoma, a cancer that arises from melanocytes is one of the most unresponsive cancers to known therapies.Extensive attention has focused on the development of new and improved methods for tackling this disease.This study aims to construct a novel nanosphere-gel for the sequential delivery of salidroside and paeonol and investigate the synergistic effects of these drugs in anti-melanogenesis, as well as to decrease their irritation and toxicological potential in high dosage.Nanospheres loaded with paeonol were prepared and characterized for the particle size, polydispersity index, zeta potential, encapsulation efficiency, drug release, and morphological properties.The optimized nanosphere formulation was incorporated in carbomer hydrogel with both paeonol and salidroside entrapped to form a dual drugs loaded nanosphere-gel.It was demonstrated that the paeonol entrapped nanosphere in the gel system were kept spherical with the size of 286±14nm (PDI 0.397+0.11) and stable.The zeta potential of the nanosphere was around-22mV.The paeonol entrapment efficacy in the nanosphere-gel system was 65.3%.
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