新型长效DPP-Ⅳ抑制剂的发现与设计

来源 :中国药理学会第十三次全国学术大会 | 被引量 : 0次 | 上传用户：ganyi123

【摘要】

：

糖尿病是当前威胁全球人类健康的最重要的慢性非传染性疾病之一.据国际糖尿病联盟(IDF)的统计表明,目前全球约3.82亿人患糖尿病,仅2013年,全球有510万人死于与糖尿病相关的疾病,占所有死亡人数的8.39％.而中国2013年糖尿病的患病人数为9840万,居全球首位;IDF估计,到2035年中国的糖尿病患病人数将达到1.43亿.DPP4抑制剂是治疗Ⅱ型糖尿病的新药,因其无低血糖、体重增加、水肿以

【作者】

：

徐洪玲李诗良赵振江徐玉芳李洪林

【机构】

：

华东理工大学药学院/上海市新药设计重点实验室,上海200237

【出处】

：

中国药理学会第十三次全国学术大会

【发表日期】

：

2015年7期

【关键词】

：

DPP-V 药物设计天然产物长效抑制剂候选药物临床前研究

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

The effect of genomic instability on vascular angiotensin Ⅱ responses:implications for aging of the

Aim Aging is the dominant risk factor for cardiovascular disease.Recently, we have shown that genomic instability, a causative mechanism of aging in general, induced by functional mutation of the ERCC

会议

The potential therapeutic effect DL0805-2 on experimental pulmonary hypertensive rats and the underl

Aim DL08052 is a novel Rhokinases inhibitor which has been found to have potent cardiovascular effects.In the present research, we aimed to study the potential of DL08052 in the treatment of pulmonary

会议

DL0805-2pulmonary artery hypertensionmechanismsmonocrotalineRho/ROCK pathway

Tanshinone Ⅱ A, the major lipophilic component of Danshen, promotes neuronal differentiation through

Danshen has been used in stroke treatment for thousands of years in China.However, the underlying mechanism still remains elusive.Neuron loss is the cardinal feature of stroke.Stimulating endogenous n

会议

tanshinone Ⅱ Astrokeneuronal differentiationmAPK42/44caveolin-1BDNFNGF

P2X7r antagonist suppressed hepatic stellate cells activation through NLPR3 inflammasome signaling

P2X7 receptor (P2X7r) is important in inflammation and fibrosis.The aim of the present study was to investigate the effect of P2X7r inhibition, using a specific inhibitor (A438079) to prevent the deve

会议

liver fibrosishepatic stellate cellsP2X7 receptorNLRP3inflammasomeIL-1β

Diabetic cognitive dysfunction: a long and strenuous way from bench to clinical

Type 2 diabetes increase the risk of development of cognitive dysfunction in the elderly, in the form of shortterm memory and executive function deficits.Genetic and dietinduced models of type 2 diabe

会议

type 2 diabetescognitive dysfunctionhyperglycemiainsulin resistanceinflammat

Total Saponins of Aralia elata (Miq.) Seem Leaves (TSAESL)Inhibits Tumor Cell Proliferation and Indu

Aim Aralia elata (Miq.) Seem is a medicinal plant with a variety of biological activities.Several trierpene saponins extracted from the leaves of Aralia elata (Miq.) Seem possess potent cytotoxic acti

会议

Aralia elata (Miq.) SeemHuman breast cancerApoptosisMAPKXenografted nude mic

Cytotoxic effect of oxaloacetate on a human hepatic carcinoma cell line HepG2 through apoptosis and

Aim Oxaloacetate (OA) is one of the intermediates in the Krebs cycle.In addition to its role in the metabolism of energy production, OA may have other effects on the cell.We report in the present stud

会议

OxaloacetateHepG2 cellApoptosisReactive oxygen species.

Synergistic and attenuated effect of active protein P23 in combination treatment with docetaxel plus

Aim Platinum based combination regimens are firstline treatment option in treatment of NSCLC but the clinical utility has been limited because of their toxicities.Many reports indicated that patients

会议

P23antitumor activityadditive effecttoxicitydocetaxelcisplatin

Roles of berbamine in the normal and ischemia/reperfusion hearts

Myocardial infarction resulting from coronary atherosclerosis is the leading cause of death in modern society.Reperfusion is an essential treatment to salvage ischemia myocardium from necrosis, while

会议

Myocardial infarctionberbaminepostconditioningautophagyischemia/reperfusion

Baicalein causes alternation in dopamine metabolism in PC12 cells by inhibiting the expression of CO

Aim Baicalein is the major flavonoid obtained from the Scutellaria root.Our previous studies have demonstrated that baicalein has a clear positive effect on recovery in an experimental model of Parkin

会议

baicaleinParkinson's diseasePC12 cellsrotenonedopaminemetabolism

新型长效DPP-Ⅳ抑制剂的发现与设计

与本文相关的学术论文